Calcium Folinate / Leucovorin Calcium EP/USP/IP is a Reduced Folate also used for colon-rectal cancer treatment and rescue remedy with some oncological therapies.
The API Calcium Folinate has been manufacturing by Cerbios for more than 30 years and is commercialized worldwide.
Calcium Folinate is mainly used in the treatment of colon rectal cancer in combination with 5-fluorouracil (5-FU) and Oxaliplatin (FOLFOX regimen) or in combination with 5-FU and Irinotecan (FOLFIRI regimen).
Additionally, it is administered as rescue therapy to reduce toxic effects after high dose therapy with methotrexate in the treatment of some neoplastic diseases, rheumatoid arthritis and severe psoriasis. Calcium Folinate is also given to treat anemia caused by folate deficiencies. For more information please refer to the general Reduced Folates chapter.