Calcipotriol / Calcipotriene Monohydrate is an HPAI Vitamin D Derivative used for the treatment of plaque psoriasis, also in combination with steroids.
Calcipotriol Monohydrate is a synthetic Vitamin D3 derivative, prescribed for once or twice-daily use in the treatment of moderate plaque psoriasis. It is commonly recommended for topical dermatological application. The combination of Calcipotriol Monohydrate with a corticosteroid improves efficacy and decreases skin irritation.
During the last years a great deal of activity has been devoted to developing analogues of Vitamin D which show the desired cell differentiating and immunomodulating activity, but with strongly reduced hypercalcemic activity.
Calcipotriol was the first Vitamin D analogue on the market and is licensed for once/twice-daily use in the treatment of moderate plaque psoriasis. Calcipotriol Monohydrate, a synthetic Vitamin D3 derivative, is commonly used for topical dermatological use as well. The Combination of Calcipotriol Monohydrate with a corticosteroid improves efficacy and decreases skin irritation.